The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
Identifieur interne : 000E34 ( Main/Exploration ); précédent : 000E33; suivant : 000E35The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
Auteurs : Cendrine Tourette [France] ; Francesca Farina [France] ; Rafael P. Vazquez-Manrique [France] ; Anne-Marie Orfila [France] ; Jessica Voisin [France] ; Sonia Hernandez [France] ; Nicolas Offner [France] ; J. Alex Parker [France] ; Sophie Menet [France] ; Jinho Kim [États-Unis] ; Jungmok Lyu [États-Unis] ; Si Ho Choi [États-Unis] ; Kerry Cormier [États-Unis] ; Christina K. Edgerly [États-Unis] ; Olivia L. Bordiuk [États-Unis] ; Karen Smith [États-Unis] ; Anne Louise [France] ; Michael Halford [Australie] ; Steven Stacker [Australie] ; Jean-Philippe Vert [France] ; Robert J. Ferrante [États-Unis] ; Wange Lu [États-Unis] ; Christian Neri [France]Source :
- PLoS Biology [ 1544-9173 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Animaux, Caenorhabditis elegans, Facteurs de transcription Forkhead (métabolisme), Femelle, Humains, Lignée cellulaire, Maladie de Huntington (métabolisme), Maladie de Huntington (étiologie), Mâle, Neurones (métabolisme), Protéines de Caenorhabditis elegans (génétique), Protéines de Caenorhabditis elegans (métabolisme), Préséniline-1 (métabolisme), Récepteurs Wnt (métabolisme), Récepteurs à activité tyrosine kinase (génétique), Récepteurs à activité tyrosine kinase (métabolisme), Souris, Souris transgéniques, Sujet âgé, Séquençage par oligonucléotides en batterie, Transporteurs de la sérotonine (génétique), Transporteurs de la sérotonine (métabolisme), Voie de signalisation Wnt.
- MESH :
- génétique : Protéines de Caenorhabditis elegans, Récepteurs à activité tyrosine kinase, Transporteurs de la sérotonine.
- métabolisme : Facteurs de transcription Forkhead, Maladie de Huntington, Neurones, Protéines de Caenorhabditis elegans, Préséniline-1, Récepteurs Wnt, Récepteurs à activité tyrosine kinase, Transporteurs de la sérotonine.
- étiologie : Maladie de Huntington.
- Adulte d'âge moyen, Animaux, Caenorhabditis elegans, Femelle, Humains, Lignée cellulaire, Mâle, Souris, Souris transgéniques, Sujet âgé, Séquençage par oligonucléotides en batterie, Voie de signalisation Wnt.
English descriptors
- KwdEn :
- Aged, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins (genetics), Caenorhabditis elegans Proteins (metabolism), Cell Line, Female, Forkhead Transcription Factors (metabolism), Humans, Huntington Disease (etiology), Huntington Disease (metabolism), Male, Mice, Mice, Transgenic, Middle Aged, Neurons (metabolism), Oligonucleotide Array Sequence Analysis, Presenilin-1 (metabolism), Receptor Protein-Tyrosine Kinases (genetics), Receptor Protein-Tyrosine Kinases (metabolism), Receptors, Wnt (metabolism), Serotonin Plasma Membrane Transport Proteins (genetics), Serotonin Plasma Membrane Transport Proteins (metabolism), Wnt Signaling Pathway.
- MESH :
- chemical , genetics : Caenorhabditis elegans Proteins, Receptor Protein-Tyrosine Kinases, Serotonin Plasma Membrane Transport Proteins.
- chemical , metabolism : Caenorhabditis elegans Proteins, Forkhead Transcription Factors, Presenilin-1, Receptor Protein-Tyrosine Kinases, Receptors, Wnt, Serotonin Plasma Membrane Transport Proteins.
- etiology : Huntington Disease.
- metabolism : Huntington Disease, Neurons.
- Aged, Animals, Caenorhabditis elegans, Cell Line, Female, Humans, Male, Mice, Mice, Transgenic, Middle Aged, Oligonucleotide Array Sequence Analysis, Wnt Signaling Pathway.
Abstract
A study of Huntington's disease reveals that neurons might fail to cope with maintaining their function during the pre-symptomatic, pathogenic phases of HD, possibly due to the early repression of key longevity-promoting transcription factors by abnormal developmental signaling.
Url:
DOI: 10.1371/journal.pbio.1001895
PubMed: 24960609
PubMed Central: 4068980
Affiliations:
- Australie, France, États-Unis
- Californie, Massachusetts, Pennsylvanie, Île-de-France
- Fontainebleau, Paris, Pittsburgh
- Université de Pittsburgh
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Le document en format XML
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Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Parker, J Alex" sort="Parker, J Alex" uniqKey="Parker J" first="J. Alex" last="Parker">J. Alex Parker</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Menet, Sophie" sort="Menet, Sophie" uniqKey="Menet S" first="Sophie" last="Menet">Sophie Menet</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jinho" sort="Kim, Jinho" uniqKey="Kim J" first="Jinho" last="Kim">Jinho Kim</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Lyu, Jungmok" sort="Lyu, Jungmok" uniqKey="Lyu J" first="Jungmok" last="Lyu">Jungmok Lyu</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Choi, Si Ho" sort="Choi, Si Ho" uniqKey="Choi S" first="Si Ho" last="Choi">Si Ho Choi</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cormier, Kerry" sort="Cormier, Kerry" uniqKey="Cormier K" first="Kerry" last="Cormier">Kerry Cormier</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Edgerly, Christina K" sort="Edgerly, Christina K" uniqKey="Edgerly C" first="Christina K." last="Edgerly">Christina K. 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xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Neri, Christian" sort="Neri, Christian" uniqKey="Neri C" first="Christian" last="Neri">Christian Neri</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes 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level="a" type="main">The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity</title><author><name sortKey="Tourette, Cendrine" sort="Tourette, Cendrine" uniqKey="Tourette C" first="Cendrine" last="Tourette">Cendrine Tourette</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Assistance Publique-Hopitaux de Paris (AP-HP), Charles Foix Hospital, Functional Exploration Unit, Ivry-sur-Seine, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique-Hopitaux de Paris (AP-HP), Charles Foix Hospital, Functional Exploration Unit, Ivry-sur-Seine</wicri:regionArea><wicri:noRegion>Ivry-sur-Seine</wicri:noRegion><wicri:noRegion>Ivry-sur-Seine</wicri:noRegion></affiliation></author><author><name sortKey="Farina, Francesca" sort="Farina, Francesca" uniqKey="Farina F" first="Francesca" last="Farina">Francesca Farina</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vazquez Manrique, Rafael P" sort="Vazquez Manrique, Rafael P" uniqKey="Vazquez Manrique R" first="Rafael P." last="Vazquez-Manrique">Rafael P. Vazquez-Manrique</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Orfila, Anne Marie" sort="Orfila, Anne Marie" uniqKey="Orfila A" first="Anne-Marie" last="Orfila">Anne-Marie Orfila</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Voisin, Jessica" sort="Voisin, Jessica" uniqKey="Voisin J" first="Jessica" last="Voisin">Jessica Voisin</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hernandez, Sonia" sort="Hernandez, Sonia" uniqKey="Hernandez S" first="Sonia" last="Hernandez">Sonia Hernandez</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Offner, Nicolas" sort="Offner, Nicolas" uniqKey="Offner N" first="Nicolas" last="Offner">Nicolas Offner</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Parker, J Alex" sort="Parker, J Alex" uniqKey="Parker J" first="J. Alex" last="Parker">J. Alex Parker</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Menet, Sophie" sort="Menet, Sophie" uniqKey="Menet S" first="Sophie" last="Menet">Sophie Menet</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jinho" sort="Kim, Jinho" uniqKey="Kim J" first="Jinho" last="Kim">Jinho Kim</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Lyu, Jungmok" sort="Lyu, Jungmok" uniqKey="Lyu J" first="Jungmok" last="Lyu">Jungmok Lyu</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Choi, Si Ho" sort="Choi, Si Ho" uniqKey="Choi S" first="Si Ho" last="Choi">Si Ho Choi</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cormier, Kerry" sort="Cormier, Kerry" uniqKey="Cormier K" first="Kerry" last="Cormier">Kerry Cormier</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Edgerly, Christina K" sort="Edgerly, Christina K" uniqKey="Edgerly C" first="Christina K." last="Edgerly">Christina K. Edgerly</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Bordiuk, Olivia L" sort="Bordiuk, Olivia L" uniqKey="Bordiuk O" first="Olivia L." last="Bordiuk">Olivia L. Bordiuk</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Smith, Karen" sort="Smith, Karen" uniqKey="Smith K" first="Karen" last="Smith">Karen Smith</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>VA Bedford Geriatric Research Education and Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>VA Bedford Geriatric Research Education and Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Louise, Anne" sort="Louise, Anne" uniqKey="Louise A" first="Anne" last="Louise">Anne Louise</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Pasteur Institute, Cytometry Platform, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pasteur Institute, Cytometry Platform, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Halford, Michael" sort="Halford, Michael" uniqKey="Halford M" first="Michael" last="Halford">Michael Halford</name><affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Peter MacCallum Cancer Center, East Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Stacker, Steven" sort="Stacker, Steven" uniqKey="Stacker S" first="Steven" last="Stacker">Steven Stacker</name><affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Peter MacCallum Cancer Center, East Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Vert, Jean Philippe" sort="Vert, Jean Philippe" uniqKey="Vert J" first="Jean-Philippe" last="Vert">Jean-Philippe Vert</name><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>Mines ParisTech, Center for Computational Biology, Fontainebleau, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Mines ParisTech, Center for Computational Biology, Fontainebleau</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Fontainebleau</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff12"><addr-line>Curie Institute, Research Center, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Curie Institute, Research Center, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff13"><addr-line>INSERM, Unit 900, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 900, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ferrante, Robert J" sort="Ferrante, Robert J" uniqKey="Ferrante R" first="Robert J." last="Ferrante">Robert J. Ferrante</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurological Surgery Department, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Lu, Wange" sort="Lu, Wange" uniqKey="Lu W" first="Wange" last="Lu">Wange Lu</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Neri, Christian" sort="Neri, Christian" uniqKey="Neri C" first="Christian" last="Neri">Christian Neri</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8256, Laboratory of Neuronal Cell Biology and Pathology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>INSERM, Unit 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 894, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS Biology</title><idno type="ISSN">1544-9173</idno><idno type="eISSN">1545-7885</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Animals</term><term>Caenorhabditis elegans</term><term>Caenorhabditis elegans Proteins (genetics)</term><term>Caenorhabditis elegans Proteins (metabolism)</term><term>Cell Line</term><term>Female</term><term>Forkhead Transcription Factors (metabolism)</term><term>Humans</term><term>Huntington Disease (etiology)</term><term>Huntington Disease (metabolism)</term><term>Male</term><term>Mice</term><term>Mice, Transgenic</term><term>Middle Aged</term><term>Neurons (metabolism)</term><term>Oligonucleotide Array Sequence Analysis</term><term>Presenilin-1 (metabolism)</term><term>Receptor Protein-Tyrosine Kinases (genetics)</term><term>Receptor Protein-Tyrosine Kinases (metabolism)</term><term>Receptors, Wnt (metabolism)</term><term>Serotonin Plasma Membrane Transport Proteins (genetics)</term><term>Serotonin Plasma Membrane Transport Proteins (metabolism)</term><term>Wnt Signaling Pathway</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Animaux</term><term>Caenorhabditis elegans</term><term>Facteurs de transcription Forkhead (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire</term><term>Maladie de Huntington (métabolisme)</term><term>Maladie de Huntington (étiologie)</term><term>Mâle</term><term>Neurones (métabolisme)</term><term>Protéines de Caenorhabditis elegans (génétique)</term><term>Protéines de Caenorhabditis elegans (métabolisme)</term><term>Préséniline-1 (métabolisme)</term><term>Récepteurs Wnt (métabolisme)</term><term>Récepteurs à activité tyrosine kinase (génétique)</term><term>Récepteurs à activité tyrosine kinase (métabolisme)</term><term>Souris</term><term>Souris transgéniques</term><term>Sujet âgé</term><term>Séquençage par oligonucléotides en batterie</term><term>Transporteurs de la sérotonine (génétique)</term><term>Transporteurs de la sérotonine (métabolisme)</term><term>Voie de signalisation Wnt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Caenorhabditis elegans Proteins</term><term>Receptor Protein-Tyrosine Kinases</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caenorhabditis elegans Proteins</term><term>Forkhead Transcription Factors</term><term>Presenilin-1</term><term>Receptor Protein-Tyrosine Kinases</term><term>Receptors, Wnt</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de Caenorhabditis elegans</term><term>Récepteurs à activité tyrosine kinase</term><term>Transporteurs de la sérotonine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Huntington Disease</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription Forkhead</term><term>Maladie de Huntington</term><term>Neurones</term><term>Protéines de Caenorhabditis elegans</term><term>Préséniline-1</term><term>Récepteurs Wnt</term><term>Récepteurs à activité tyrosine kinase</term><term>Transporteurs de la sérotonine</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladie de Huntington</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Animals</term><term>Caenorhabditis elegans</term><term>Cell Line</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Transgenic</term><term>Middle Aged</term><term>Oligonucleotide Array Sequence Analysis</term><term>Wnt Signaling Pathway</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Animaux</term><term>Caenorhabditis elegans</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire</term><term>Mâle</term><term>Souris</term><term>Souris transgéniques</term><term>Sujet âgé</term><term>Séquençage par oligonucléotides en batterie</term><term>Voie de signalisation Wnt</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A study of Huntington's disease reveals that neurons might fail to cope with maintaining their function during the pre-symptomatic, pathogenic phases of HD, possibly due to the early repression of key longevity-promoting transcription factors by abnormal developmental signaling.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kikis, Ea" uniqKey="Kikis E">EA Kikis</name></author><author><name sortKey="Gidalevitz, T" uniqKey="Gidalevitz T">T 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Vazquez-Manrique</name><name sortKey="Vert, Jean Philippe" sort="Vert, Jean Philippe" uniqKey="Vert J" first="Jean-Philippe" last="Vert">Jean-Philippe Vert</name><name sortKey="Vert, Jean Philippe" sort="Vert, Jean Philippe" uniqKey="Vert J" first="Jean-Philippe" last="Vert">Jean-Philippe Vert</name><name sortKey="Vert, Jean Philippe" sort="Vert, Jean Philippe" uniqKey="Vert J" first="Jean-Philippe" last="Vert">Jean-Philippe Vert</name><name sortKey="Voisin, Jessica" sort="Voisin, Jessica" uniqKey="Voisin J" first="Jessica" last="Voisin">Jessica Voisin</name><name sortKey="Voisin, Jessica" sort="Voisin, Jessica" uniqKey="Voisin J" first="Jessica" last="Voisin">Jessica Voisin</name><name sortKey="Voisin, Jessica" sort="Voisin, Jessica" uniqKey="Voisin J" first="Jessica" last="Voisin">Jessica Voisin</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Kim, Jinho" sort="Kim, Jinho" uniqKey="Kim J" first="Jinho" last="Kim">Jinho Kim</name></region><name sortKey="Bordiuk, Olivia L" sort="Bordiuk, Olivia L" uniqKey="Bordiuk O" first="Olivia L." last="Bordiuk">Olivia L. Bordiuk</name><name sortKey="Choi, Si Ho" sort="Choi, Si Ho" uniqKey="Choi S" first="Si Ho" last="Choi">Si Ho Choi</name><name sortKey="Cormier, Kerry" sort="Cormier, Kerry" uniqKey="Cormier K" first="Kerry" last="Cormier">Kerry Cormier</name><name sortKey="Edgerly, Christina K" sort="Edgerly, Christina K" uniqKey="Edgerly C" first="Christina K." last="Edgerly">Christina K. Edgerly</name><name sortKey="Ferrante, Robert J" sort="Ferrante, Robert J" uniqKey="Ferrante R" first="Robert J." last="Ferrante">Robert J. Ferrante</name><name sortKey="Lu, Wange" sort="Lu, Wange" uniqKey="Lu W" first="Wange" last="Lu">Wange Lu</name><name sortKey="Lyu, Jungmok" sort="Lyu, Jungmok" uniqKey="Lyu J" first="Jungmok" last="Lyu">Jungmok Lyu</name><name sortKey="Smith, Karen" sort="Smith, Karen" uniqKey="Smith K" first="Karen" last="Smith">Karen Smith</name></country><country name="Australie"><noRegion><name sortKey="Halford, Michael" sort="Halford, Michael" uniqKey="Halford M" first="Michael" last="Halford">Michael Halford</name></noRegion><name sortKey="Stacker, Steven" sort="Stacker, Steven" uniqKey="Stacker S" first="Steven" last="Stacker">Steven Stacker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
}}
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